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cell line gl261 luc  (Revvity)


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    Revvity cell line gl261 luc
    Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in <t>GL261</t> cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
    Cell Line Gl261 Luc, supplied by Revvity, used in various techniques. Bioz Stars score: 92/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell line gl261 luc/product/Revvity
    Average 92 stars, based on 7 article reviews
    cell line gl261 luc - by Bioz Stars, 2026-02
    92/100 stars

    Images

    1) Product Images from "Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity"

    Article Title: Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity

    Journal: Yonsei Medical Journal

    doi: 10.3349/ymj.2022.0414

    Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
    Figure Legend Snippet: Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Techniques Used: Irradiation, Expressing

    Effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Dose versus clonogenic survival curves and immunofluorescence images of phosphor-γ-H2AX. GL261- luc cells were treated with PI3K isoform-selective inhibitors for 24 h (doses ranging from 0.1 to 10 µM). Data are expressed as the percentage of (B) MTT cell proliferation assay. (C) Protein expression of AKT activation in GL261- luc . Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
    Figure Legend Snippet: Effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Dose versus clonogenic survival curves and immunofluorescence images of phosphor-γ-H2AX. GL261- luc cells were treated with PI3K isoform-selective inhibitors for 24 h (doses ranging from 0.1 to 10 µM). Data are expressed as the percentage of (B) MTT cell proliferation assay. (C) Protein expression of AKT activation in GL261- luc . Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Techniques Used: Irradiation, Immunofluorescence, MTT Cell Proliferation, Expressing, Activation Assay

    Combination effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Clonogenic survival curves: GL261- luc were treated with PI3K isoform-selective inhibitor at 1 h after 1 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after combination of radiation and PI3K isoform inhibitors (CON vs. IR only; *** , CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** , CON vs. IR+CAL101; *** , CON vs. IR+IPI145; ** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 0.1 µM. Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
    Figure Legend Snippet: Combination effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Clonogenic survival curves: GL261- luc were treated with PI3K isoform-selective inhibitor at 1 h after 1 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after combination of radiation and PI3K isoform inhibitors (CON vs. IR only; *** , CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** , CON vs. IR+CAL101; *** , CON vs. IR+IPI145; ** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 0.1 µM. Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Techniques Used: Irradiation, Expressing

    Inhibition of the PI3K-α isoform increases radiosensitivity in brain tumor in vivo. After intracranial implant of GL261- luc cells, 10 Gy irradiation with or without GDC0032 (5 mg/kg). (A) IVIS imaging of mouse brain tumors from within 7–16 days post therapy. (B) Kaplan–Meier survival analysis (p: CON vs. IR only; * , CON vs. IR+GDC0032; ** ). Statistical significance was set at p <0.05. * p <0.05; ** p <0.01. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
    Figure Legend Snippet: Inhibition of the PI3K-α isoform increases radiosensitivity in brain tumor in vivo. After intracranial implant of GL261- luc cells, 10 Gy irradiation with or without GDC0032 (5 mg/kg). (A) IVIS imaging of mouse brain tumors from within 7–16 days post therapy. (B) Kaplan–Meier survival analysis (p: CON vs. IR only; * , CON vs. IR+GDC0032; ** ). Statistical significance was set at p <0.05. * p <0.05; ** p <0.01. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Techniques Used: Inhibition, In Vivo, Irradiation, Imaging



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    Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in <t>GL261</t> cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.
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    Image Search Results


    Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Journal: Yonsei Medical Journal

    Article Title: Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity

    doi: 10.3349/ymj.2022.0414

    Figure Lengend Snippet: Combination effect of irradiation and PI3K isoform inhibitors in the LN229 human glioma cell line. (A) Clonogenic survival curves: LN229 were treated with PI3K isoform-selective inhibitor at 1 h after 2 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after a combination of radiation and PI3K isoform inhibitors ( p : CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 1 µMs. Statistical significance was set at p <0.05. *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Article Snippet: The mouse-derived cell line GL261- luc (purchased from PerkinElmer, Waltham, MA, USA) and human-derived cell line LN229 (purchased from ATCC, Manassas, VA, USA) were used in the present study.

    Techniques: Irradiation, Expressing

    Effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Dose versus clonogenic survival curves and immunofluorescence images of phosphor-γ-H2AX. GL261- luc cells were treated with PI3K isoform-selective inhibitors for 24 h (doses ranging from 0.1 to 10 µM). Data are expressed as the percentage of (B) MTT cell proliferation assay. (C) Protein expression of AKT activation in GL261- luc . Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Journal: Yonsei Medical Journal

    Article Title: Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity

    doi: 10.3349/ymj.2022.0414

    Figure Lengend Snippet: Effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Dose versus clonogenic survival curves and immunofluorescence images of phosphor-γ-H2AX. GL261- luc cells were treated with PI3K isoform-selective inhibitors for 24 h (doses ranging from 0.1 to 10 µM). Data are expressed as the percentage of (B) MTT cell proliferation assay. (C) Protein expression of AKT activation in GL261- luc . Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Article Snippet: The mouse-derived cell line GL261- luc (purchased from PerkinElmer, Waltham, MA, USA) and human-derived cell line LN229 (purchased from ATCC, Manassas, VA, USA) were used in the present study.

    Techniques: Irradiation, Immunofluorescence, MTT Cell Proliferation, Expressing, Activation Assay

    Combination effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Clonogenic survival curves: GL261- luc were treated with PI3K isoform-selective inhibitor at 1 h after 1 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after combination of radiation and PI3K isoform inhibitors (CON vs. IR only; *** , CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** , CON vs. IR+CAL101; *** , CON vs. IR+IPI145; ** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 0.1 µM. Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Journal: Yonsei Medical Journal

    Article Title: Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity

    doi: 10.3349/ymj.2022.0414

    Figure Lengend Snippet: Combination effect of irradiation and PI3K isoform inhibitors in the GL261 mouse glioma cell line. (A) Clonogenic survival curves: GL261- luc were treated with PI3K isoform-selective inhibitor at 1 h after 1 Gy irradiation. (B) Expression of phosphor-γ-H2AX in GL261 cells after combination of radiation and PI3K isoform inhibitors (CON vs. IR only; *** , CON vs. IR+GDC0941; *** , CON vs. IR+GDC0032; *** , CON vs. IR+CAL101; *** , CON vs. IR+IPI145; ** ). Treatment doses were GDC0941 0.1 µM, GDC0032 0.1 µM, CAL101 1 µM, and IPI145 0.1 µM. Statistical significance was set at p <0.05. ** p <0.01; *** p <0.001. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Article Snippet: The mouse-derived cell line GL261- luc (purchased from PerkinElmer, Waltham, MA, USA) and human-derived cell line LN229 (purchased from ATCC, Manassas, VA, USA) were used in the present study.

    Techniques: Irradiation, Expressing

    Inhibition of the PI3K-α isoform increases radiosensitivity in brain tumor in vivo. After intracranial implant of GL261- luc cells, 10 Gy irradiation with or without GDC0032 (5 mg/kg). (A) IVIS imaging of mouse brain tumors from within 7–16 days post therapy. (B) Kaplan–Meier survival analysis (p: CON vs. IR only; * , CON vs. IR+GDC0032; ** ). Statistical significance was set at p <0.05. * p <0.05; ** p <0.01. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Journal: Yonsei Medical Journal

    Article Title: Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity

    doi: 10.3349/ymj.2022.0414

    Figure Lengend Snippet: Inhibition of the PI3K-α isoform increases radiosensitivity in brain tumor in vivo. After intracranial implant of GL261- luc cells, 10 Gy irradiation with or without GDC0032 (5 mg/kg). (A) IVIS imaging of mouse brain tumors from within 7–16 days post therapy. (B) Kaplan–Meier survival analysis (p: CON vs. IR only; * , CON vs. IR+GDC0032; ** ). Statistical significance was set at p <0.05. * p <0.05; ** p <0.01. PI3K, phosphoinositide 3-kinase; AKT, protein kinase B.

    Article Snippet: The mouse-derived cell line GL261- luc (purchased from PerkinElmer, Waltham, MA, USA) and human-derived cell line LN229 (purchased from ATCC, Manassas, VA, USA) were used in the present study.

    Techniques: Inhibition, In Vivo, Irradiation, Imaging